Are Reels/Sequences AR- and resolution agnostic?

Hello

Is it possible to have an 1.5 AspectRatio Reel if in the the project setup and AR of 1.778 is definded?

Or are Reels/Sequences totally AR- and resolution agnostic (and their resolution and AR does only depend on the first imported clip)?

Thank you!

Any resolution information at the Project level is nothing more than a starting default numerical field.